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M94A2785.TXT
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1994-10-25
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Document 2785
DOCN M94A2785
TI Use of granulocyte colony stimulating factor (G-CSF) in patients with
HIV infections.
DT 9412
AU Miguelez M; Laynez P; Linarez M; Romero F; Rosquete J; Antolin J;
Servicio de Medicina Interna Hospital Ntra. Sra. de Candelaria,; Santa
Cruz de Tenerife, Espana.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):225 (abstract no. PB0329). Unique
Identifier : AIDSLINE ICA10/94369790
AB OBJECTIVE: HIV neutropenia is a common event that may result from
hematopoietic failure due to infections, secondary to an adverse drug
toxicity, malignancy and dysmyelopoiesis. G-CSF may have beneficial
effects in the management of neutropenia in AIDS pts. METHODS: During a
one-year period, G-CSF were used in 6 HIV infected pts. with severe
neutropenia. G-CSF was administered at daily doses of 5 mgr/Kgr, s.c.
RESULTS: Prior to receiving G-CSF the mean base-line absolute neutrophil
count was < 500/mm3. The mean duration of therapy was 15.2 days (range:
8-26); the mean absolute neutrophil count at the end of treatment was
17.560/mm3 (range: 2370-43,000). Cause of neutropenia were felt to be
secondary to adverse drug toxicity in 3 pts. (2 AZT, 1 chemotherapy for
HS), opportunistic infections in 1 patient (TB) and dysmyelopoiesis in 2
pts. All pts were in group IV-C1, according to the classification system
of the CDC. Temporally bone pain was the only reported toxicity of G-CSF
in one patient. CONCLUSIONS: G-CSF may have in short term therapy
beneficial effects in the management of HIV neutropenia.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY
AIDS-Related Opportunistic Infections/COMPLICATIONS Biological Response
Modifiers/*THERAPEUTIC USE Comparative Study Drug Evaluation
Granulocyte Colony-Stimulating Factor/*THERAPEUTIC USE Human Leukocyte
Count Myelodysplastic Syndromes/COMPLICATIONS
Neutropenia/ETIOLOGY/*THERAPY Tuberculosis/COMPLICATIONS
Zidovudine/ADVERSE EFFECTS/THERAPEUTIC USE MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).